Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC24
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-12-08 16:18
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment madopar 3x1\4

Overall Assessment

non PD

Subject performance similar to non PD population

Clinical context

In the clinical reference population, 7 individuals with a value less than 0.53 were subsequently diagnosed with PD. That is, 16.67% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.53 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 1, 'TN': 2, 'TP': 41, 'FP': 28}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 42, 'TN': 30, 'TP': 0, 'FP': 0}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 27, 'TN': 21, 'TP': 15, 'FP': 9}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 11, 'TN': 8, 'TP': 31, 'FP': 22}

Test Battery Details

Circle

numCircles 9
timePerCircleMean 16.9022
timePerCircleCoV 0.383615
timePerCircleSlope 0.0423219
meanError 1.94338
tremorFreq 5.07812
tremorRelPower 54.0007
tremorGyroAmpMean 0.246141
tremorGyroAmpSlope 0.0221015
tremorGyroAmpCoV 1.52017
tremorCoordAmpMean 0.352427
tremorCoordAmpSlope 0.0199561
tremorCoordAmpCoV 1.30441
tremorAccAmpMean 0.266434
tremorAccAmpSlope 0.0161174
tremorAccAmpCoV 1.06791
tremorPcRelVar 0.937944
tremorPcX -0.680009
tremorPcY -0.733204

Circle Segment 1

Duration 14.32 s, Accuracy Estimate 1.147 (lower is better)

Circle Segment 2

Duration 13.92 s, Accuracy Estimate 1.31 (lower is better)

Circle Segment 3

Duration 14.64 s, Accuracy Estimate 1.127 (lower is better)

Circle Segment 4

Duration 14.0 s, Accuracy Estimate 1.423 (lower is better)

Circle Segment 5

Duration 15.16 s, Accuracy Estimate 1.461 (lower is better)

Circle Segment 6

Duration 16.6 s, Accuracy Estimate 1.185 (lower is better)

Circle Segment 7

Duration 30.64 s, Accuracy Estimate 3.405 (lower is better)

Circle Segment 8

Duration 24.0 s, Accuracy Estimate 3.529 (lower is better)

Circle Segment 9

Duration 8.84 s, Accuracy Estimate 2.903 (lower is better)

Spiral

numSpirals 4
timePerSpiralMean 43.16
timePerSpiralCoV 0.156098
timePerSpiralSlope 0.018721
meanError 2.45623
tremorFreq 4.98047
tremorRelPower 71.5425
tremorGyroAmpMean 0.289593
tremorGyroAmpSlope -0.000892634
tremorGyroAmpCoV 1.94063
tremorCoordAmpMean 0.335533
tremorCoordAmpSlope -0.00249001
tremorCoordAmpCoV 1.77922
tremorAccAmpMean 0.265673
tremorAccAmpSlope -0.00235587
tremorAccAmpCoV 1.58081
tremorPcRelVar 0.955861
tremorPcX -0.592514
tremorPcY -0.80556

Spiral Segment 1

Duration 48.2 s, Accuracy Estimate 3.151 (lower is better)

Spiral Segment 2

Duration 35.08 s, Accuracy Estimate 2.114 (lower is better)

Spiral Segment 3

Duration 40.16 s, Accuracy Estimate 2.022 (lower is better)

Spiral Segment 4

Duration 49.2 s, Accuracy Estimate 2.538 (lower is better)

Elel

eDurationMean 1.13524
eDurationStd 0.171048
eDurationStdnorm 0.150671
eDurationMedian 1.16
eDurationQuartdelta 0.32
eDurationQuartdeltanorm 0.275862
eDurationKurt 1.69913
eDurationTrenddiff 0.045
eDurationTrendratio 1.04
eWidthMean 5.73021
eWidthStd 1.09771
eWidthStdnorm 0.191565
eWidthMedian 5.616
eWidthQuartdelta 1.521
eWidthQuartdeltanorm 0.270833
eWidthKurt 2.78346
eWidthTrenddiff -0.585
eWidthTrendratio 0.903846
eHeightMean 10.8782
eHeightStd 1.68314
eHeightStdnorm 0.154725
eHeightMedian 10.7055
eHeightQuartdelta 1.989
eHeightQuartdeltanorm 0.185792
eHeightKurt 4.59477
eHeightTrenddiff -0.468
eHeightTrendratio 0.956989
eAspectMean 0.531958
eAspectStd 0.0956147
eAspectStdnorm 0.179741
eAspectMedian 0.5298
eAspectQuartdelta 0.0916369
eAspectQuartdeltanorm 0.172965
eAspectKurt 4.94583
eAspectTrenddiff -0.0573232
eAspectTrendratio 0.898661
eSlantMean 0.0911589
eSlantStd 0.136817
eSlantStdnorm 1.50086
eSlantMedian 0.0854803
eSlantQuartdelta 0.186813
eSlantQuartdeltanorm 2.18545
eSlantKurt 3.75568
eSlantTrenddiff -0.0426471
eRtopMean 0.825261
eRtopStd 0.0827606
eRtopStdnorm 0.100284
eRtopMedian 0.826837
eRtopQuartdelta 0.123862
eRtopQuartdeltanorm 0.149803
eRtopKurt 2.37001
eRtopTrenddiff 0.0540376
eRbotMean 0.667855
eRbotStd 0.243879
eRbotStdnorm 0.365168
eRbotMedian 0.652368
eRbotQuartdelta 0.346154
eRbotQuartdeltanorm 0.530611
eRbotKurt 3.95359
eRbotTrenddiff 0.121184
eRrightMean 0.895154
eRrightStd 0.0655253
eRrightStdnorm 0.0732001
eRrightMedian 0.906759
eRrightQuartdelta 0.0915475
eRrightQuartdeltanorm 0.100961
eRrightKurt 4.05375
eRrightTrenddiff 0.0402116
eRleftMean 0.366152
eRleftStd 0.100942
eRleftStdnorm 0.275683
eRleftMedian 0.35558
eRleftQuartdelta 0.124883
eRleftQuartdeltanorm 0.351209
eRleftKurt 3.46741
eRleftTrenddiff -0.0184874
lDurationMean 1.44637
lDurationStd 0.20451
lDurationStdnorm 0.141395
lDurationMedian 1.405
lDurationQuartdelta 0.31
lDurationQuartdeltanorm 0.220641
lDurationKurt 2.52483
lDurationTrenddiff 0.06
lDurationTrendratio 1.04356
lWidthMean 8.39768
lWidthStd 1.4765
lWidthStdnorm 0.175822
lWidthMedian 8.424
lWidthQuartdelta 1.8135
lWidthQuartdeltanorm 0.215278
lWidthKurt 2.88661
lWidthTrenddiff -1.2285
lWidthTrendratio 0.86
lHeightMean 21.3379
lHeightStd 3.38846
lHeightStdnorm 0.1588
lHeightMedian 20.709
lHeightQuartdelta 4.446
lHeightQuartdeltanorm 0.214689
lHeightKurt 3.68404
lHeightTrenddiff -1.6965
lHeightTrendratio 0.92246
lAspectMean 0.396749
lAspectStd 0.0585243
lAspectStdnorm 0.14751
lAspectMedian 0.394901
lAspectQuartdelta 0.0888819
lAspectQuartdeltanorm 0.225074
lAspectKurt 2.38498
lAspectTrenddiff 0.00398243
lAspectTrendratio 1.01016
lSlantMean 0.122012
lSlantStd 0.0973099
lSlantStdnorm 0.797544
lSlantMedian 0.117888
lSlantQuartdelta 0.162354
lSlantQuartdeltanorm 1.37718
lSlantKurt 2.38155
lSlantTrenddiff -0.00795183
lRtopMean 0.848608
lRtopStd 0.0617311
lRtopStdnorm 0.072744
lRtopMedian 0.855595
lRtopQuartdelta 0.0709852
lRtopQuartdeltanorm 0.0829658
lRtopKurt 2.7962
lRtopTrenddiff -0.0264484
lRbotMean 0.555441
lRbotStd 0.217128
lRbotStdnorm 0.390911
lRbotMedian 0.522131
lRbotQuartdelta 0.307936
lRbotQuartdeltanorm 0.589768
lRbotKurt 3.99731
lRbotTrenddiff 0.0154125
lRrightMean 0.902302
lRrightStd 0.0479385
lRrightStdnorm 0.0531292
lRrightMedian 0.903704
lRrightQuartdelta 0.0649144
lRrightQuartdeltanorm 0.0718315
lRrightKurt 2.73872
lRrightTrenddiff -0.00751896
lRleftMean 0.273238
lRleftStd 0.105163
lRleftStdnorm 0.384878
lRleftMedian 0.260194
lRleftQuartdelta 0.103953
lRleftQuartdeltanorm 0.39952
lRleftKurt 3.93877
lRleftTrenddiff -0.0137793

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.745862
sumTouchScores 11.9338
meanMovementTime 1.12533
numTouches 16
undershootPercentage 0
overshootPercentage 12.5

FITTS Long Modified

meanTouchScore 0.719573
sumTouchScores 9.35445
meanMovementTime 1.26708
numTouches 13
undershootPercentage 7.69231
overshootPercentage 23.0769

ZigZag

numZigzags 5
timePerZigzagMean 28.896
timePerZigzagCoV 0.0161314
timePerZigzagSlope 0.00816722
meanError 2.11568
tremorFreq 5.66406
tremorRelPower 66.1815
tremorGyroAmpMean 0.19264
tremorGyroAmpSlope 0.00230584
tremorGyroAmpCoV 0.511349
tremorCoordAmpMean 0.308113
tremorCoordAmpSlope 0.00203567
tremorCoordAmpCoV 0.375891
tremorAccAmpMean 0.289214
tremorAccAmpSlope 0.00194177
tremorAccAmpCoV 0.33225
tremorPcRelVar 0.908767
tremorPcX 0.0341187
tremorPcY -0.999418

ZigZag Segment 1

Duration 28.68 s, Accuracy Estimate 1.686 (lower is better)

ZigZag Segment 2

Duration 28.2 s, Accuracy Estimate 2.196 (lower is better)

ZigZag Segment 3

Duration 29.0 s, Accuracy Estimate 2.358 (lower is better)

ZigZag Segment 4

Duration 29.28 s, Accuracy Estimate 2.144 (lower is better)

ZigZag Segment 5

Duration 29.32 s, Accuracy Estimate 2.195 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 23.224
timePerZigzagCoV 0.0366299
timePerZigzagSlope -0.0077506
zigzagHeightMean 58.3981
zigzagHeightCoV 0.0442522
zigzagHeightSlope -0.0210247
meanError 0.0248766
tremorFreq 5.76172
tremorRelPower 70.7489
tremorGyroAmpMean 0.250043
tremorGyroAmpSlope -0.00643751
tremorGyroAmpCoV 0.47833
tremorCoordAmpMean 0.319128
tremorCoordAmpSlope -0.00531111
tremorCoordAmpCoV 0.419949
tremorAccAmpMean 0.29862
tremorAccAmpSlope -0.00497949
tremorAccAmpCoV 0.359953
tremorPcRelVar 0.902207
tremorPcX 0.0676147
tremorPcY 0.997712

ZigZag Offset Segment 1

Duration 23.28 s, Accuracy Estimate 0.021 (lower is better)

ZigZag Offset Segment 2

Duration 23.08 s, Accuracy Estimate 0.019 (lower is better)

ZigZag Offset Segment 3

Duration 23.8 s, Accuracy Estimate 0.02 (lower is better)

ZigZag Offset Segment 4

Duration 24.08 s, Accuracy Estimate 0.023 (lower is better)

ZigZag Offset Segment 5

Duration 21.88 s, Accuracy Estimate 0.042 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘PD’, ‘HiSpec_score’: 0.34}
RanFor {‘RanFor_class’: ‘NOT PD’, ‘RanFor_score’: 0.53}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.5383416803610039}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9103900157148501}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.38706182359730756}